منابع مشابه
[Association between paraoxonase-1 and paraoxonase-2 polymorphisms and the risk of acute myocardial infarction].
INTRODUCTION AND OBJECTIVES Two particular polymorphisms, namely PON1-192 and PON2-311, in the genes encoding the antioxidant enzymes paraoxonase-1 (PON1) and paraoxonase-2 (PON2) have been associated with an increased risk of acute myocardial infarction (AMI). However, previous findings have been contradictory. The aim of this study was to investigate the association between the PON1-192 and P...
متن کاملAlzheimer’s Disease and Paraoxonase 1 (PON1) Gene Polymorphisms
BACKGROUND Some studies have indicated that human paraoxonase 1 (PON1) activity shows a polymorphic distribution. The aim of this study was to determine the distribution of PON1 polymorphism in patients with Alzheimer's disease in Gorgan and compare it with a healthy control group. METHOD The study included 100 healthy individuals and 50 patients. Enzyme activity and genetic polymorphism of P...
متن کاملParaoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus.
Paraoxonase 1 (PON1), an antioxidant enzyme closely associated with HDL (high-density lipoproteins), preserves LDL (low-density lipoproteins) against oxidation. Less protection may be therefore supposed by decreased PON1 activity. This study was undertaken to investigate the association of PON1 gene polymorphisms with diabetic angiopathy and to evaluate the relationship of these polymorphisms w...
متن کاملGenetic polymorphisms of paraoxonase 1 and susceptibility to atherogenesis.
INTRODUCTION Paraoxonase 1 (PON1) is a multifunctional enzyme associated with high-density lipoprotein particles (HDL). It is a cellular antioxidant that hydrolyses oxidized macromolecules, especially low-density lipoproteins (ox-LDL). Because increased oxidative stress is believed to play a crucial role in the initiation and propagation of atherosclerosis, coding (Q192R and L55M) and promoter ...
متن کاملParaoxonase 1 (PON1) Activity, Polymorphisms and Coronary Artery Disease
Cardiovascular disorders (CVD) which include coronary artery disease (CAD), heart failure (HF) and stroke are the leading cause of morbidity and mortality both in developed and developing countries and by 2020 CAD is expected to become the number one cause of death worldwide 1-3. As per WHO, CVD kills nearly 17.5 million persons worldwide each year and is likely to continue to remain number one...
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ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2004
ISSN: 1018-4813,1476-5438
DOI: 10.1038/sj.ejhg.5201235